Heteroatoms-containing tricyclic compounds

US5200411A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Andrew Edmunds · Chur, CH
• Maximilian Grassberger · Wien, AT

Key dates

• Filing date: Jun 13, 1991
• Grant date: Apr 6, 1993
• Expiry date: Jun 13, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/01
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds of formula I ##STR1## wherein the substituents have various significances, possess pharmacological, particularly antiinflammatory and immunosuppressant activity. They can be prepared by one or more of the following process variants: reduction, deprotection, acylation, reaction with N,N'-carbonyl- or N,N'-thiocarbonyldiimidazole, halogenation, splitting off of hydrogen halide, reaction with a hydrogen carbonate, radical deoxygenation, dehydration or reaction with diazomethane of -ethane, optionally under transient protection of reactive groups which it is not desired to react.