Benzimidazole derivatives, their preparation and use

US5200422A · kind A · utility

Assignee

• Neurosearch A/S · DK

Inventors

• Soren Olesen · Klampenborg, DK
• Frank Watjen · Frederikssund, DK

Key dates

• Filing date: Jul 17, 1991
• Grant date: Apr 6, 1993
• Expiry date: Jul 17, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D235/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound having the formula ##STR1## wherein R.sup.1 is hydrogen, NH.sub.2 or C.sub.1-6 -alkyl which may be branched; PA1 X is O, S, NCN; PA1 Y is O, S; PA1 R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, CF.sub.3, NO.sub.2, NH.sub.2, OH, C.sub.1-6 -alkoxy, C(.dbd.O)-phenyl or SO.sub.2 NR.sup.I R.sup.II wherein R.sup.I and R.sup.II independently are hydrogen or C.sub.1-6 -alkyl; PA1 R.sup.11 is hydrogen, halogen, NO.sub.2 or SO.sub.2 NR'R" wherein R' and R" independently are hydrogen or C.sub.1-6 -alkyl; PA1 R.sup.13 is hydrogen, halogen, phenyl, CF.sub.3, NO.sub.2 ; PA1 R.sup.12 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated; PA1 R.sup.14 is hydrogen or together with R.sup.13 forms a C.sub.4-7 -carbocyclic ring which may be aromatic or partially saturated; PA1 pharmaceutical compositions thereof, and a method of treating a disease in a mammal, including a human, responsive to opening of potassium channels, which comprises administering to a mammal in need thereof an effective amount of a compound as first above indicated, are disclosed.