Process for the production of threo-4-alkoxy-5- (arylhydroxymethyl)-2(5H)-furanones
US5200531A · kind A · utility
0Cited by
1References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Dec 17, 1991 |
| Grant date | Apr 6, 1993 |
| Priority date | — |
| Expiry date | Dec 17, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Threo-4-alkoxy-5-(arylhydroxymethyl)-2(5H)-furanones are obtained by condensation of 4-alkoxy-2(5H)-furanones with benzaldehydes in the presence of lithium hydroxide without contamination by the corresponding erythro stereoisomers. The condensation is preferably performed in aqueous acetonitrile and the product is precipitated from the alkaline reaction mixture by the addition of water. The products that can be produced according to the process of the invention are known pharmaceutical active ingredients with anticonvulsive or antiepileptic action.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.