Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants
US5202110A · kind A · utility
59Cited by
1References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1992 |
| Grant date | Apr 13, 1993 |
| Priority date | — |
| Expiry date | Jan 22, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Beclomethasone diproprionate (BDP) forms a clathrate with HCFC-123, dimethyl ether (DME) and HCFC-141b which are less harmful propellants than the CFC propellants currently used in metered dose inhalers (MDIs). The clathrate can be remicronized and suspended for use in an MDI. BDP also is completely dissolved by DME based propellant blends and certain HCFC 123 propellant blends. Using propellant blends which completely dissolve BDP will assure more efficient dosing with an MDI.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.