Preparation method of microdispersed tablet formulation of spray-dried sodium diclofenac enteric-coated microcapsules
US5202159A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 31, 1990 |
| Grant date | Apr 13, 1993 |
| Priority date | — |
| Expiry date | Dec 31, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A preparation method of sodium diclofenac enteric-coated microcapsules by spray drying technique comprising the steps of PA1 (a) dissolving sodium diclofenac in an appropriate amount of distilled water; PA1 (b) adding an effective amount of excipients to the above solution to form a suspension; PA1 (c) adding methacrylic acid-ethyl acrylate copolymers (Eudragit L 30D) and polyethyleneglycol 6000 (PEG 6000) as the enteric-coating material to form a slurry; PA1 (d) atomizing the slurry to form spray-dried powder; PA1 (e) mixing the spray-dried powder with a mixture of microcrystalline cellulose (neocel) and pregelatinized starch (flo-starch); and PA1 (f) compressing the powder mixture into a microdispersed enteric tablet. The spray drying technique could be easily performed to prepare the enteric-coated microcapsules with aqueous latex polymer dispersion such as Eudragit L 30D as an enteric-coating polymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.