Immunosuppressant-producing culture
US5202258A · kind A · utility
1Cited by
1References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1992 |
| Grant date | Apr 13, 1993 |
| Priority date | — |
| Expiry date | Mar 9, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/827
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described is a new microorganism, Actinoplanacete sp., (Merck Culture Collection MA 6559) ATCC No. 53771. The microorganism acts as a demethylating agent and can produce the new immunosuppressants, "demethomycin" (L-682,993) a C-31 demethylated analog of L-679,934, and "demethimmunomycin" (L-683,742) a C-31 demethylated analog of L-683,590, under novel fermentation conditions. These macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.