Cyclosporine metabolites
US5202310A · kind A · utility
25Cited by
3References
10Claims
0Family size
Inventors
Key dates
| Filing date | Jun 6, 1990 |
| Grant date | Apr 13, 1993 |
| Priority date | — |
| Expiry date | Jun 6, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A cyclosporine metabolite having a molecular weight determined by mass spectrometry of about 1205 and having the following properties: (a) being immunologically distinct from cyclosporine metabolites OL-1, OL-17 and OL-8; (b) being more polar than OL-1 or OL-17 and less polar than OL-8 when eluated from a gradient high performance liquid chromatography; (c) being extractable from bile of test animals which have been administered cyclosporine A; and (d) being substantially free of other cyclosporine metabolites and cyclosporine A, and a physiologically acceptable salt or stereoisomer thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.