Patent · US Expired

Rapamycin analog as immunosuppressant

US5202332A · kind A · utility

39Cited by
2References
1Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 5, 1992
Grant dateApr 13, 1993
Priority date—
Expiry dateAug 5, 2012

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H19/01
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Reduction of the C-33 ketone of rapamycin gives the C-33 hydroxy analog of Formula I. ##STR1## The reduction product prevents cleavage of the C-31/C-32 bond due to base degradation. The Formula I compounds exhibit immunosuppressant, antifungal, and antiinflammatory activities.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.