Antiflammatory quinolin methoxy phenylsulphonamides

US5202336A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Klaus-Helmut Mohrs · Wuppertal, DE
• Elisabeth Perzborn · Wuppertal, DE
• Friedel Seuter
• Romanis Fruchtmann · Cologne, DE
• Christian Kohlsdorfer · Lechenich, DE

Key dates

• Filing date: Jul 12, 1991
• Grant date: Apr 13, 1993
• Expiry date: Jul 12, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New phenylsulphonamide of the formula in which ##STR1## R.sup.1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy, cyano, nitro, halogenoalkyl, halogenoalkoxy, alkoxycarbonyl or alkylsulphonyl, PA0 R.sup.2 represents hydrogen, cyano, nitro, halogen, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy or alkoxycarbonyl, PA0 R.sup.3 represents an aryl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted by halogen, halogenoalkyl, halogenoalkoxy, alkyl, alkoxy, alkylthio, alkylsulphonyl, cyano, nitro or alkoxycarbonyl, the substituents being identical or different, or represents pentafluorophenyl or represents a straight-chain, branched or cyclic alkyl which is unsubstituted or substituted by halogen, aryl, aryloxy, cyano, alkoxycarbonyl, alkoxy, alkylthio or trifluoromethyl, and PA0 X represents an --O--, --A--B-- or --B--A-- group, where PA0 A denotes ##STR2## and B denotes ##STR3## where R.sup.1 does not represent a pyridyl radical when X represents an --O-- group, and salts thereof are prepared by reacting appropriate amines with sulphonyl halides. The substituted phenylsulphonam…