Protease absorbent for isolating and purifying proteases, a process for the preparation therefor, and the method for purifying a protease

US5202416A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Werner Stuber · Lahntal, DE
• Eric-Paul Paques · Marburg, DE

Key dates

• Filing date: Aug 10, 1989
• Grant date: Apr 13, 1993
• Expiry date: Aug 10, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/6456
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Peptide derivatives of the Formula I EQU R--Y--Leu--Pro--NH--CH(CH.sub.2 --CH.sub.2 --CH.sub.2 --NH--C(.dbd.NH)--NH.sub.2)--X in which Y is HN--(CH.sub.2).sub.n --CO with n=1 to 8 or a bond, X is CN, CH.sub.2 OH or CHO and R is a support or a hydrogen atom, a process for the preparation thereof, and the use thereof for affinity chromatography, especially for isolating and purifying proteases, are described.