Reversed phase chromatographic process

US5204005A · kind A · utility

Assignee

• MALLINCKRODT LLC · US

Inventors

• Narciso Ocampo Doran, III · Bridgeton, US
• Thomas J. Dunn · Cedar Hill, US
• Mills T. Kneller · University City, US
• Youlin Lin · Chesterfield, US
• David H. White · Ballwin, US
• David M. Wong · Kirkwood, US

Key dates

• Filing date: Jan 28, 1991
• Grant date: Apr 20, 1993
• Expiry date: Jan 28, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/46
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

An improved process for the reversed phase chromatographic decolorization, separation, and purification of water-soluble, nonionic contrast media compounds from solutions containing nonionic compound impurities involves the steps of (a) packing a chromatographic column with a chromatographic packing material; (b) passing through the column a solution containing a water-soluble, nonionic contrast media compound and nonionic compounds as impurities at a loading ratio between approximately 10 to 1 and 1.5 to 1 wt. packing material/total wt. nonionic compounds; and (c) eluting the column to produce an eluate containing substantially pure, water-soluble, nonionic contrast media compound or MRI agent. The process can be economically practiced on a factory scale and efficiently removes non-polar impurities difficult to remove by conventional methods.