Medicaments having controlled release of the active compound

US5204121A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Manfred Bucheler · Overath, DE
• Andreas Ohm · Neuss, DE
• Roland Rupp · Bensberg, DE
• Josef Schmoll · Wermelskirchen, DE
• Axel Wollenschlager · Bensberg, DE

Key dates

• Filing date: Jan 30, 1990
• Grant date: Apr 20, 1993
• Expiry date: Jan 30, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/5073
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Controlled release medicament pellets comprising PA0 a) a core which contains as active ingredient a compound of the formula ##STR1## or a compound from the group of 3-(4-fluorophenylsulphonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid or 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3 (2H)-one 1,1-dioxide monohydrochloride, an intensive disintegrating agent, a wetting agent and a binder, PA0 b) a double layer which controls release comprising PA1 (b1) an acrylic-based outer undigestible water-permeable lacquer layer, and PA1 (b2) an inner jacket layer comprising a hydrophobic additive and hydroxypropylcellulose of type M or H.