Recombinant poxvirus internal cores
US5204243A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 14, 1990 |
| Grant date | Apr 20, 1993 |
| Priority date | — |
| Expiry date | Feb 14, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/24143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
What is described is a modified recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, having an internal core containing DNA from a non-pox source in a nonessential region of the poxvirus genome. The recombinant poxvirus is modified by disassociating the internal core from outer membranes of the poxvirus. The DNA codes for and expresses a gene product in a cell cultured in vitro and in a host in vivo without productive replication of the virus in the cell or in the host. What is also described is a vaccine containing the modified recombinant poxvirus for inducing an immunological response in a host inoculated with the vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.