Production of chimeric antibodies by homologous recombination
US5204244A · kind A · utility
250Cited by
0References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1988 |
| Grant date | Apr 20, 1993 |
| Priority date | — |
| Expiry date | Sep 14, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for producing chimeric antibodies using novel recombinant DNA vectors and homologous recombination in vivo is described. The recombinant DNA constructs of the invention can be used to transfect antibody producing cells so that targeted homologous recombination occurs in the transfected cells leading to gene modification and the production of chimeric antibody molecules by the transfected cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.