Compounds exhibiting anti-parasitic activity and a method for their use

US5204352A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Richard Sundberg · Bro, SE
• Daniel J. Dahlhausen · Columbus, US
• Govindarajan Manikumar · Raleigh, US
• Babu J. Mavunkel · Sunnyvale, US
• Hikmat A. Musallam · Damascus, US
• Atanu Biswas · Cleveland, US
• Srinivasan Varadarajan · Stow, US

Key dates

• Filing date: Sep 29, 1987
• Grant date: Apr 20, 1993
• Expiry date: Sep 29, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel compounds are provided which exhibit high levels of anti-parasitic activity, specifically against parasites of the genus Trypanosoma. The compounds are comprised of aryl-substituted quaternary heteroaromatic salts which include a positively charged imidazolium or other heterocyclic ring, a linking group, a phenyl ring, and a polar functional group. The polar functional group is preferably a quanylhydrazone or a heterocyclic hydrazone. A method is also provided for treating the diseases associated with Trypanosoma parasites which comprises administering to infected animals or humans an effective amount of a compound of the present invention.