Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by heterocycles

US5204374A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Muller · Wuppertal, DE
• Ulrich Rosentreter · Binnen, DE
• Ulrich Niewohner · Wermelskirchen, DE
• Elisabeth Perzborn · Wuppertal, DE
• Erwin Bischoff · Wuppertal, DE
• Hans-Georg Dellweg · Wuppertal, DE
• Peter Norman · Warwick, GB
• Nigel J. Cuthbert · Tiverton, GB
• Hilary P. Francis · Kenilworth, GB

Key dates

• Filing date: Apr 3, 1991
• Grant date: Apr 20, 1993
• Expiry date: Apr 3, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and PA0 represent hydrogen, nitro, cyano, halogen, trifluoromethyl, carboxyl, hydroxyl or trifluoromethoxy, or PA0 represent a group of the formula --S(O).sub.w R.sup.5, in which PA1 R.sup.5 denotes alkyl or optionally substituted aryl, PA1 w denotes the number 0, 1 or 2, or PA2 represents alkoxy or alkoxycarbonyl, or benzyloxy, or PA2 represents a group of the formula --NR.sup.6 R.sup.7, in which PA3 R.sup.6 and R.sup.7 are identical or different and PA4 denote hydrogen, alkyl or acyl or PA4 denote aryl, or PA4 denote a group of the formula --S(O).sub.w R.sup.5, in which R.sup.5 and w have the abovementioned meaning, PA4 represent cycloalkyl or PA4 represent optionally substituted alkyl or alkenyl, PA4 m represents the number 1, 2, 3 or 4, PA4 n represents the number 0, 1 or 2, PA4 z represents the number 1, 2, 3 or 4, PA4 A represents a bond or the --NH group, PA4 X represents an optionally substituted heterocycle, PA4 Y represents hydroxyl, alkoxy, phenoxy or a group of the formula --NR.sup.6…