Method for inhibiting heparanase activity
US5206223A · kind A · utility
10Cited by
5References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1990 |
| Grant date | Apr 27, 1993 |
| Priority date | — |
| Expiry date | Sep 17, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/715
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Heparanase activity in a patient may be inhibited by administering an effective heparanase-inhibiting amount of heparin or an effective chemically modified derivative of heparin which inhibits heparanase activity. Such derivatives are preferably N-desulfated, N-acetylated heparin or O-desulfated, N-acetylated heparin. By means of this invention, allograft rejection may be prevented or delayed and autoimmune diseases such as arthritis may be alleviated and treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.