Method for the treatment of malaria

US5206236A · kind A · utility

Inventors

• Richard R. Tidwell · Pittsboro, US
• J. Dieter Geratz · Chapel Hill, US
• James E. Hall · Chapel Hill, US
• Dennis E. Kyle · Athens, US
• Max Grogl · Silver Spring, US
• Kwasi Ohemeng · Clinton, US

Key dates

• Filing date: Sep 5, 1991
• Grant date: Apr 27, 1993
• Expiry date: Sep 5, 2011

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for treating malaria which comprises to an afflicted host patient a therapeutically effective amount of a compound have the structure of formula I: ##STR1## wherein X is O or NH; R.sub.1 is H or two R.sub.1 groups on the same amidine group together represents --(CH.sub.2).sub.m --, wherein m=2, 3 or 4; R.sub.2 is H, NH.sub.2, Cl, NO.sub.2 ; R.sub.3 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and n=2-6 or a pharmaceutically acceptable salt thereof provided that when X is O, both R.sub.2 and both R.sub.3 can not be H.