Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds

US5206253A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Elmar Bosies · Weinheim, DE
• Frieder Bauss · Lambsheim, DE

Key dates

• Filing date: Nov 25, 1991
• Grant date: Apr 27, 1993
• Expiry date: Nov 25, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6506
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention concerns novel disphosphonates having the general formula I ##STR1## in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if desired, and which can also be partially hydrogenated, PA1 R.sub.1 -R.sub.7 each denote, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl, PA1 X=denotes hydrogen, OH or the group --NR.sub.8 R.sub.9, in which R.sub.8 and R.sub.9 should each be, independently of each other, hydrogen or C.sub.1 -C.sub.5 alkyl, PA1 m and n denote, independently of each other, 0, 1 or 2, as well as their pharmacologically safe salts and optically active forms.