Oligopetides with cyclic proline-analogous amino acids

US5206343A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Stephan Henke · Bad Soden am Taunus, DE
• Dietrich Brocks · Wiesbaden, DE
• Volkmar Gunzlen-Pukall · Marburg, DE
• Kari Kivirikko · Oulu, FI
• Raili Myllyla · Oulu, FI

Key dates

• Filing date: Jun 1, 1989
• Grant date: Apr 27, 1993
• Expiry date: Jun 1, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of the formula I ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl compound; D represents NH, NCH.sub.3, O or CH.sub.2 ; E represents CHOH, CO, SO or optionally N-substituted C.dbd.NH; F represents O, NH, NCH.sub.3 or a bond; R.sup.4 denotes an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R.sup.8 denotes hydrogen or optionally substituted alkyl, to a process for the preparation thereof, and to the use thereof as inhibitors of prolyl hydroxylase.