Actinonin derivatives and pharmaceutically acceptable salts thereof
US5206384A · kind A · utility
60Cited by
3References
6Claims
0Family size
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Key dates
| Filing date | Sep 4, 1991 |
| Grant date | Apr 27, 1993 |
| Priority date | — |
| Expiry date | Sep 4, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel actinonin derivative and a salt thereof are provided, which are useful as enzyme inhibitors and particularly have strong inhibitory activities against enkephalinase and angiotensin-converting enzymes. This actinonin derivative is represented by general formula (I): ##STR1## wherein R.sup.1 is sulfoxymethyl or carboxyl or a substituted carboxyl group selected from carboxamide, hydroxyaminocarbonyl and alkoxycarbonyl groups; and R.sup.2 is hydroxyl, alkoxy, hydroxyamino or sulfoxyamino group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.