Iontophoretic drug delivery system with two-stage delivery profile
US5207752A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 21, 1991 |
| Grant date | May 4, 1993 |
| Priority date | — |
| Expiry date | Mar 21, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/325
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A two-stage iontophoretic drug delivery system provides that iontophoretic current is delivered at a first level for a first predetermined interval to rapidly introduce a therapeutic agent into the bloodstream and thereafter reduced to a second lower level to maintain a desired steady-state therapeutic level of the agent. One embodiment provides that the initial interval is maintained sufficiently long to provide a peak dosage, thereafter which the current is shut off to allow concentration of the agent to subside in the bloodstream, whereupon a maintenance level of iontophoretic current is initiated. Another embodiment provides that the patient may selectively initiate a brief interval of increased iontophoretic current level to attain a brief interval of increased dosage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.