Regioselective chemical modification of monoclonal antibodies
US5208008A · kind A · utility
6Cited by
1References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 14, 1990 |
| Grant date | May 4, 1993 |
| Priority date | — |
| Expiry date | Nov 14, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.