Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5208230A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 25, 1992 |
| Grant date | May 4, 1993 |
| Priority date | — |
| Expiry date | Jun 25, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of the formula ##STR1## wherein A is methylene, oxygen, sulfur or N-B wherein B is R.sub.1 or COR.sub.2 wherein R.sub.1 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Z-- group wherein Ar is aryl and Z is a C.sub.0 -C.sub.4 alkyl and R.sub.2 is a --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Z group; PA1 R is hydrogen or a C.sub.1 -C.sub.4 alkyl; and PA1 X and Y are each independently hydrogen, nitro or amino, with the proviso that when X is nitro or amino, Y must be hydrogen, and when Y is nitro or amino, X must be hydrogen; and pharmaceutically acceptable salts thereof, which are inhibitors of Angiotensin Converting Enzyme.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.