Thioester enantiomeric compounds and their therapeutic uses
US5208255A · kind A · utility
92Cited by
3References
6Claims
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Key dates
| Filing date | Nov 22, 1988 |
| Grant date | May 4, 1993 |
| Priority date | — |
| Expiry date | Nov 22, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.