Immunoenzymatic method in homogeneous phase for the determination of anti-plasmodium falciparum-sporozoite antibodies in human blood
US5210018A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 20, 1989 |
| Grant date | May 11, 1993 |
| Priority date | — |
| Expiry date | Apr 20, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An immunoenzymatic method for the detection of anti-Plasmodium falciparum-sporozoite antibodies in a sample of human blood, which operates, in homogeneous phase, and under suitable conditions, with a synthetic polypeptidic antigen (P), a synthetic antigen-enzyme (P-E) conjugate, wherein said antigen is capable of specifically reacting with the anti-Plasmodium falciparum-sporozoite antibodies (Ab) possibly present in the sample, and an inert substance capable of quantitatively precipitating the antibody-synthetic antigen-enzyme complex (Ab-P-E). The method, due to its specificity, sensitivity, reproducibility and rapidity, is particularly useful in the epidemiological investigations into malaria and in the evaluation of the efficacy of an antimalarial vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.