Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
US5210031A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1992 |
| Grant date | May 11, 1993 |
| Priority date | — |
| Expiry date | Feb 3, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/846
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting an epihalohydrin with a halohydrin-halide-lyase originating from a microorganism selected from the group consisting of: Corynebacterium sp. N-2354 FERM BP-2726 and Microbacterium sp. N-4701 FERM BP-2644 in the presence of an alkali cyanide to thereby convert the epihalohydrin into the 4-halo-3-hydroxybutyronitrile and collecting the product thus formed is disclosed. According to this process, a 4-halo-3-hydroxybutyronitrile which is highly useful in the syntheses of various medicines and physiologically active substances can be easily and efficiently produced from an inexpensive starting material.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.