Method for preparing a phosphonic acid ester
US5210262A · kind A · utility
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2References
9Claims
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Key dates
| Filing date | Sep 14, 1992 |
| Grant date | May 11, 1993 |
| Priority date | — |
| Expiry date | Sep 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing a phosphonic acid ester having the structure ##STR1## wherein R.sup.1 is farnesyl or a derivative or analog thereof, and R.sup.2 is lower alkyl, by treating a farnesyl halide R.sup.1 Hal(Hal=Cl,Br,I) with an alkoxide of the structure ##STR2## wherein M is an alkali metal and R.sup.2c is lower alkyl. The resulting phosphonic acid ester is an intermediate in preparing a squalene synthetase inhibitor which is used for inhibiting cholesterol biosynthesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.