Method of determining a cite of inflammation utilizing elam-1 ligands site

US5211936A · kind A · utility

Assignee

• Glycomed Incorporated · US

Inventors

• Brian K. Brandley · Alameda, US
• Michael Tiemeyer · Oakland, US
• Stuart J. Swiedler · Oakland, US
• Margaret Moreland · Berkeley, US
• Hans Schweingruber · Mountain View, US

Key dates

• Filing date: Jul 30, 1990
• Grant date: May 18, 1993
• Expiry date: Jul 30, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation and assay for the presence of (qualitative) and amount of (quantitative) ELAM-1 and thereby determine the presence, location and degree of inflammation. The ligands are encompassed by general structural formula I as follows: ##STR1## wherein one of F and G is hydrogen and one is an N-acetyl neuraminic acid residue on the terminal unit and are both hydrogen on any other unit; J is hydrogen, a lactosylceramide or a linking group and K is hydrogen or a fucose residue and n is an integer of from 1 to 10 (preferably 3 or 4) with the proviso that n and K are defined such that at least one K is a fucose residue.