Anthracycline derivatives as solubilized pro-drugs
US5212291A · kind A · utility
24Cited by
2References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1992 |
| Grant date | May 18, 1993 |
| Priority date | — |
| Expiry date | Mar 9, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/252
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.