1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5214038A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1991 |
| Grant date | May 25, 1993 |
| Priority date | — |
| Expiry date | Apr 15, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to compounds of the formula ##STR1## wherein PA1 R.sub.1 is hydrogen or loweralkyl; PA1 R.sub.2 is hydrogen or loweralkyl; and PA1 R.sub.3 is hydrogen, loweralkyl, halogen, nitro, amino, hydroxy, loweralkoxy, benzyloxy or ##STR2## PA1 where R.sub.4 is hydrogen or loweralkyl and R.sub.5 is loweralkyl, aryl or arylloweralkyl, or R.sub.4 and R.sub.5 taken together form a heterocyclic ring selected from the group consisting of ##STR3## PA1 wherein PA1 R.sub.6 is hydrogen, loweralkyl, aryl or arylloweralkyl or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful for alleviating depression and various memory dysfunctions characterized by a cholinergic or adrenergic deficit, such as Alzheimer's Disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.