Amino acid containing acrylamide derivatives for ulcer prevention or treatment
US5214045A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1990 |
| Grant date | May 25, 1993 |
| Priority date | — |
| Expiry date | Jul 11, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel acrylic amide derivatives of the Formula (I) ##STR1## wherein R.sup.1 represents a hydrogen or a halogen atom or a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group. PA0 n is an integer of 0 to 2, PA0 A represents an amino acid residue derived from a naturally occurring amino acid or an antipode thereof which is bonded to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid, bonded to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C.sub.1-4 alkyl group or is amidated; or A represents a group of the formula ##STR2## wherein R.sub.2 is a hydrogen atom or a phenyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxycarbonyl group, and their salts which have cytoprotective and antiulcer to activities. A process is also described for the preparation of said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.