Esters of castanospermine in the treatment of cerebral malaria
US5214050A · kind A · utility
2Cited by
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Key dates
| Filing date | Mar 5, 1992 |
| Grant date | May 25, 1993 |
| Priority date | — |
| Expiry date | Mar 5, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.