1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
US5214058A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 27, 1991 |
| Grant date | May 25, 1993 |
| Priority date | — |
| Expiry date | Jun 27, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl; PA1 R.sub.2 is hydrogen, loweralkyl, loweralkenyl, formyl or cyano; PA1 X is hydrogen, halogen, nitro, amino, loweralkyl, loweralkoxy or hydroxy; PA1 Y is hydrogen, loweralkyl, loweralkoxy, arylloweralkoxy, hydroxy, halogen, nitro or amino, with the proviso that when Y is hydrogen or loweralkyl, R.sub.1 is not hydrogen and R.sub.2 is not formyl; a pharmaceutically acceptable acid addition salt thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof. The compounds of the invention are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function, such as found in Alzheimer's disease and other senile dementia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.