Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents
US5214068A · kind A · utility
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7Claims
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Key dates
| Filing date | Mar 12, 1992 |
| Grant date | May 25, 1993 |
| Priority date | — |
| Expiry date | Mar 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C311/49
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Sulfonylhydrazines of the formula RSO.sub.2 N(CH.sub.2 CH.sub.2 X)N(SO.sub.2 CH.sub.3).sub.2, wherein R is an alkyl or an aryl and X is a halogen or OSO.sub.2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydrazines are useful in treating cancer. Methylating agents of the formula PA1 (a) R'SO.sub.2 N(CH.sub.3)N(SO.sub.2 CH.sub.3).sub.2, wherein R' is an alkyl or an aryl and PA1 (b) R"SO.sub.2 N(CH.sub.3)N(CH.sub.3)SO.sub.2 R", wherein R" is an alkyl or an aryl. Such methylating agents are useful as antitrypanosomal and anticancer agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.