Apparatus and method for establishing a temperature gradient in a chromatography column
US5215556A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1992 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Apr 15, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/3023
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Apparatus and method for temperature gradient capillary gas chromatography wherein the chromatography column is surrounded by an inner tube and the inner tube is surrounded by an outer tube. A first heat transfer fluid is heated to a first temperature and is flowed between the inner tube and the column in the same direction as the flow of carrier gas through the capillary column. A second heat transfer fluid is heated to a second temperature and is flowed in the opposite direction between the outer tube and the inner tube, the second temperature being lower than the first temperature. The invention is also an improved capillary gas chromatography method of the type that generally includes the steps of flowing a carrier gas through a capillary gas chromatography column to a detector, introducing a sample to be analyzed into the column and then detecting chromatographically resolved components of interest of the sample, the method having an optimum carrier gas velocity through the column, wherein the improvement of the instant invention is to establish a negative temperature gradient along at least a portion of the longitudinal length of the capillary gas chromatography column and to…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.