Benzamide and nicotinamide radiosensitizers
US5215738A · kind A · utility
67Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 1990 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Jun 1, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for radiosensitizing hypoxic tumor cells in a warm-blooded animal is provided. The method involves administration of a nicotinamide compound having the structural formula ##STR1## wherein X is O or S, and Z is H, OR, SR or NHR where R is as defined herein. Exemplary compounds for use in conjunction with the disclosed method include: 5-hydroxynicotinamide; 5-hydroxynicotinamide, sodium salt; 5-(2,3-dihydroxypropoxy)nicotinamide; 5-aminonicotinamide; 5-(2-methoxyethylamino)nicotinamide; and 5-acetamidonicotinamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.