Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds

US5215970A · kind A · utility

Assignee

• MEDIVIR AB · SE

Inventors

• Roelf Datema · Cheshire, US
• Zsuzanna M. I. Kovacs · Albenga, IT
• Karl N. G. Johansson · Fagersta, SE
• Bjorn Lindborg · Björnlunda, SE
• Goran B. Stening · Gately Drive, SE
• Bo F. Oberg · Uppsala, SE

Key dates

• Filing date: Nov 20, 1991
• Grant date: Jun 1, 1993
• Expiry date: Nov 20, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the formula ##STR1## wherein the radicals A, X, R.sup.1, R.sup.2 and R.sup.3 are defined as follows: ##STR2## R.sup.2 : H; or R.sup.2 constitutes together with R.sup.3 with a carbon - carbon bond PA0 R.sup.3 : H; F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 ; CH.sub.2 OH; and when R.sup.3 is F; Cl; Br; I; N.sub.3 ; CN; C.tbd.CH; OH; OCH.sub.3 or CH.sub.2 OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R.sup.3 constitutes together with R.sup.2 a carbon - carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV infections.