Aminoalkoxyphenyl derivatives, process of preparation and compositions containing the same

US5215988A · kind A · utility

Assignee

• Sanofi · FR

Inventors

• Jean Gubin · Brussels, BE
• Pierre Chatelain · Brussels, BE
• Marcel Descamps · Kraainem, BE
• Dino Nisato · Pavia, IT
• Henri Inion · Wemmel, BE
• Jean Lucchetti · Chastre, BE
• Jean-Marie Mahaux · Brussels, BE
• Jean-Noel Vallat · Toulouse, FR

Key dates

• Filing date: Aug 14, 1991
• Grant date: Jun 1, 1993
• Expiry date: Aug 14, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to aminoalkoxyphenyl compounds of formula: ##STR1## in which: B is selected from --S--, --SO-- and --SO.sub.2 --, PA1 R.sub.1 and R.sub.2, which are identical or different, are selected from hydrogen, methyl, ethyl and halogen, PA1 A is selected from a straight- or branched-alkylene radical having from 2 to 5 carbon atoms, a 2-hydroxypropylene radical, and a 2-(lower alkoxy) propylene radical, PA1 R.sub.3 is selected from C.sub.1 -C.sub.8 alkyl and a radical of formula: EQU --Alk--Ar PA1 in which Alk is selected from a single bond and a linear- or branched-alkylene radical having from 1 to 5 carbon atoms; and Ar is selected from pyridyl, phenyl, 2-3-methyleneoxyphenyl, 3,4-methylenedioxyphenyl and phenyl substituted with one or more substituents, which may be identical or different, selected from halogen atoms, C.sub.1 -C.sub.8 alkyl groups and C.sub.1 -C.sub.8 alkoxy groups, PA1 R.sub.4 is selected from hydrogen and C.sub.1 -C.sub.8 alkyl, or PA1 R.sub.3 and R.sub.4, when taken together, denote a 1,4-tetra-methylene, 1,5-pentamethylene, 3-oxa-1,5-pentamethylene, 3-aza-1,5-pentamethylene, 3-methylaza-1,5-pentamethylene, 3-phenylaza-1,5-pentamethylene o…