Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents

US5215989A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• David A. Claremon · Audubon, US
• Jason Matthew Elliott · Blue Bell, US
• Gerald S. Ponticello · Lansdale, US
• David C. Remy · North Wales, US
• Harold G. Selnick · Ambler, US

Key dates

• Filing date: Jul 15, 1991
• Grant date: Jun 1, 1993
• Expiry date: Jul 15, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of structural formula: ##STR1## wherein Ar is an aromatic ring, B is a cyclic moiety fused to Ar of 5-7 members, X and Y are bridging groups, Q is a nitrogen containing heterocycle, R.sup.2 and R.sup.3 are H, substituted or unsubtituted C.sub.1-3 alkyl, C.sub.1-3 alkoxy, N(R).sub.2, halogen, CF.sub.3 or R.sup.5 and R.sup.1 is H or an aryl group.