Furo-coumarinsulfonamides as protein kinase C inhibitors
US5216014A · kind A · utility
14Cited by
4References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1991 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Sep 10, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel furocoumarinsufonamide derivatives having the formula ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H or lower alkyl; m, n and p are independently 2, 3, 4, 5 or 6; A is NR.sub.4 (CH.sub.2).sub.P NR.sub.5, NR.sub.6, O or S; R.sub.2 is independently H, lower alkyl or a moiety of the formula ##STR2## useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.