Process for the production of 4-amino-2-chloro-5-cyano-6-(methylthio)pyrimidine
US5216160A · kind A · utility
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Key dates
| Filing date | Apr 8, 1992 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Apr 8, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/47
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-Amino-2-chloro-5-cyano-6-(methylthio)primidine is produced from dicyanoketene dimethyl thioacetal and cyanamide by condensation in the presence of a base and subsequent cyclization in the presence of hydrochloric acid. The dicyanoketenedimeth thioacetal is available by reaction of malononitrile, with carbon disulfide and a base and subsequent methylation with dimethyl sulfate. The reaction sequence yields the pyrimidine derivative in good yield and practically free of by-products.
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