N-substituted aminoquinolines as analgesic agents
US5216165A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 20, 1992 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Mar 20, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein R is hydrogen, halo or trifluoromethyl; PA1 R.sup.1 is hydrogen or X; PA1 R.sup.2 is hydrogen or X; with the proviso that when R.sup.1 is X, R.sup.2 is hydrogen, and when R.sup.1 is hydrogen, R.sup.2 is X; PA1 X is the moiety ##STR2## wherein R.sup.3 is hydrogen or lower alkyl; PA2 R.sup.4 is hydrogen or ##STR3## R.sup.5 is hydrogen, alkyl of 1-16 carbon atoms, phenyl, phenylloweralkyl or perfluoroloweralkyl; PA2 Y is CO or a bond; PA2 R.sup.6 is lower alkyl, cycloloweralkyl, arylalkyl, --(CH.sub.2).sub.m -cycloloweralkyl, ##STR4## or --(CH.sub.2).sub.o CONR.sup.8 R.sup.9 or, in the case when Y is CO, phenyl; PA2 R.sup.7 is hydrogen or ##STR5## R.sup.8 and R.sup.9 are, independently, hydrogen, lower alkyl, cycloloweralkyl or R.sup.8 and R.sup.9 together with the nitrogen atom to which they are attached form a 5-8 membered saturated monoazacyclic ring; PA2 m is 1-3; PA2 n is 1-3; PA2 o is 1-10; and the pharmacologically acceptable salts thereof and, which by virtue of their ability to antagonize bradykinin, are analgesic agents useful in the treatment and management of pain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.