Process for synthesis of .sup.11 C-labeled methyl iodide and apparatus
US5217675A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 18, 1991 |
| Grant date | Jun 8, 1993 |
| Priority date | — |
| Expiry date | Jun 18, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B59/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In a process for the synthesis of .sup.11 C-labeled methyl iodide which comprises producing .sup.11 CO.sub.2 by the irradiation of a proton beam, supplying .sup.11 CO.sub.2 gas to a collector of .sup.11 CO.sub.2 gas, bubbling .sup.11 CO.sub.2 gas into a reducing agent solution to reduce .sup.11 CO.sub.2, removing the reducing agent solution by evaporation, synthesizing .sup.11 CH.sub.3 I from the reduced product of .sup.11 CO.sub.2, and recovering .sup.11 CH.sub.3 I by distillation, the termination point of the .sup.11 CO.sub.2 gas supply, the termination point of the bubbling, the termination point of the evaporation of the reducing agent solution or the termination point of the distillatin of .sup.11 CH.sub.3 I is decided by a radiation sensor provided in the vicinity of the reaction vessel or a transfer tube connecting the target box wherein .sup.11 CO.sub.2 gas is generated or a temperature sensor provide in an exhaust tube of the reaction vessel. The synthesizing time is shortened, and the yield of .sup.11 CH.sub.3 I is improved by improving the utilization of .sup.11 CO.sub.2 gas and the recovery of .sup.11 CH.sub.3 I of which the half-life is very short.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.