Method for stimulating the secretion of ACTH by administration of IL-1B analogues
US5217714A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1989 |
| Grant date | Jun 8, 1993 |
| Priority date | — |
| Expiry date | Sep 19, 2009 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/2006
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for testing the inducibility of the hypothalamus to effect the secretion of andrenocorticotropic hormone comprising the steps of: PA0 (a) administering to a test subject a pharmaceutically effective amount of a derivative of human IL-1.beta. selected from the group consisting of human IL-1.beta. [7-153], human IL-1.beta. [1-148], human IL-1.beta. [Gly.sup.4 ], human IL-1.beta. [Leu.sup.93 ] and human IL-1.beta. [des Arg.sup.98]; and PA0 (b) measuring an increase in blood levels of at least one of adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone, wherein the degree of increase in said blood levels of at least one of adrenocorticotropic hormone, cortisol and corticotropin-releasing hormone, corresponds to the degree of inducibility of the hypothalamus and is not substantially due to the induction of fever.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.