Method to produce immunodiagnostic reagents
US5217869A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 11, 1988 |
| Grant date | Jun 8, 1993 |
| Priority date | — |
| Expiry date | Oct 11, 2008 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Screening methods to obtain suitable antibodies for use in immunoassays for analytes not ordinarily susceptible to detection by this means involves in vitro screening of panels of cells secreting a representative selection of antibodies. An application of this method also permits the preparation of specific mimotopes which mimic the immunological activity of the desired analyte, which mimotopes can then be used as competitors in the immunoassay or can be used to immunize subject mammals in order to improve the specificity and affinity of the antibodies. Methods to identify a particular analyte by its pattern of binding strength to a panel of related antibodies and to match an arbitrary analyte with an immunoreactive member of a panel of candidate antibodies are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.