Composition for the stabilization of deferoxamine to chelate free ions in physiological fluid
US5217998A · kind A · utility
25Cited by
17References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 1991 |
| Grant date | Jun 8, 1993 |
| Priority date | — |
| Expiry date | Jun 17, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for scavenging free iron or aluminum in fluids such as physiological fluids involves a provision in such fluids of a soluble polymer substrate having chelator immobilized thereon. According to the invention preferred such compounds comprise polysaccharides or proteins having a deferoxamine moiety thereon. Such a compound can be used for the treatment of iron overload, as well as to inhibit cell damage from oxidation/reduction reactions. In one embodiment, cell damage during reperfusion is inhibited, through provision of the chelating moiety at the site of reperfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.