Retro-inverso analogues of thymopentin and the method for their synthesis
US5218089A · kind A · utility
13Cited by
5References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 26, 1991 |
| Grant date | Jun 8, 1993 |
| Priority date | — |
| Expiry date | Nov 26, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described which are of the general formula (I) ##STR1## where R is hydrogen or an acyl radical, and R.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.