Gas and oxygen carrying lipid vesicles
US5219538A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 1, 1991 |
| Grant date | Jun 15, 1993 |
| Priority date | — |
| Expiry date | Mar 1, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the production of lipid vesicles having a moderately volatile material such as a perfluorocarbon or a silicone oil encapsulated therein. In another aspect, lipid vesicles having a gas-filled center or core are made. The lipid vesicles having gas-filled central core are made by dehydrating vesicles having the moderately volatile liquid encapsulated in the central core. This drives off the water first, allowing the moderately volatile liquid to stabilize the vesicle structure as it dries, finally forming a central void which can refract light. The preferred vesicles of the invention are paucilamellar vesicles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.