Method for labeling proteins with technetium or rhenium

US5219555A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Karl-Heinz Bremer · Bad Soden am Taunus, DE
• Ludwig Kuhlmann · Flörsheim, DE
• Michael Magerstadt · Hofheim, DE
• Alexander Schwarz · Soest, DE
• Axel Steinstrasser · Liederbach, DE

Key dates

• Filing date: Aug 25, 1988
• Grant date: Jun 15, 1993
• Expiry date: Aug 25, 2008

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine derivatives of the formula I and/or II ##STR1## in which R.sup.1 -R.sup.7, Y, m, n, o, p, f, g, h, i and j have the stated meanings, and to the use of these labeled substances, especially in medical diagnosis.